2020s

2025

Resilience of striatal synaptic plasticity over early structural adaptations in premotor parkinsonism.

Merino-Galán L, Zamarbide M, Belloso-Iguerategui A, Alonso-Moreno MC, Gago B, Reinares-Sebastián A, Blesa J, Dumitriu D, Quiroga-Varela A, Rodríguez-Oroz MC.

NPJ Parkinsons Disease Jun 3;11(1):146 doi: 10.1038/s41531-025-00994-1

Loss of Glutaminase 1 in Small Sensory Neurons Prevents Nerve Injury Induced Mechanical Allodynia: Insights From Conditional Knockout Mice.

Martínez-Padilla A, Márquez J, Huerta MÁ, Roza C, Cisneros E.

European Journal of Pain Jul;29(6):e70069 doi: 10.1002/ejp.70069

A fluorescent protein C-terminal fusion knock-in is functional with TRPA1 but not TRPC5.

Tragl A, Ptakova A, Sinica V, Meerupally R, König C, Roza C, Barvík I, Vlachova V, Zimmermann K.

Biochimica et Biophysica Acta. Molecular Cell Research Feb;1872(2):119887 doi: 10.1016/j.bbamcr.2024.119887

New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease.

Romero-Zerbo SY, Valverde N, Claros S, Zamorano-Gonzalez P, Boraldi F, Lofaro FD, Lara E, Pavia J, Garcia-Fernandez M, Gago B, Martin-Montañez E.

Journal of Advance Research Jan;67:349-359 doi: 10.1016/j.jare.2024.01.036

2024

Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit.

Belloso-Iguerategui A, Zamarbide M, Merino-Galan L, Rodríguez-Chinchilla T, Gago B, Santamaria E, Fernández-Irigoyen J, Cotman CW, Prieto GA, Quiroga-Varela A, Rodríguez-Oroz MC.

Brain Dec 1;146(12):4949-4963 doi: 10.1093/brain/awad227

P2X3 and P2X2/3 receptors inhibition produces a consistent analgesic efficacy: A systematic review and meta-analysis of preclinical studies.

Huerta MÁ, Marcos-Frutos D, Nava J, García-Ramos A, Tejada MÁ, Roza C.

European Journal of Pharmacology Dec 5;984:177052 doi: 10.1016/j.ejphar.2024.177052

Strategies for measuring non-evoked pain in preclinical models of neuropathic pain: Systematic review.

Huerta MÁ, Cisneros E, Alique M, Roza C.

Neuroscience and Biobehavioral Reviews Aug;163:105761 doi: 10.1016/j.neubiorev.2024.105761

Comparative Gene Signature of Nociceptors Innervating Mouse Molar Teeth, Cranial Meninges, and Cornea.

Sotelo-Hitschfeld P, Bernal L, Nazeri M, Renthal W, Brauchi S, Roza C, Zimmermann K.

Anesthesia and Analgesia Jul 1;139(1):226-234 doi: 10.1213/ANE.0000000000006816

New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease.

Romero-Zerbo SY, Valverde N, Claros S, Zamorano-Gonzalez P, Boraldi F, Lofaro FD, Lara E, Pavia J, Garcia-Fernandez M, Gago B, Martin-Montañez E.

Journal of Advance Research Jan;67:349-359 doi: 10.1016/j.jare.2024.01.036

2023

Identification of Potential Visceral Pain Biomarkers in Colon Exudates from Mice with Experimental Colitis: An Exploratory In Vitro Study.

Cisneros E, Martínez-Padilla A, Cardenas C, Márquez J, Ortega de Mues A, Roza C.

The Journal of Pain May;24(5):874-887 doi: 10.1016/j.jpain.2023.01.001

2022

Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism.

Merino-Galán L, Jimenez-Urbieta H, Zamarbide M, Rodríguez-Chinchilla T, Belloso-Iguerategui A, Santamaria E, Fernández-Irigoyen J, Aiastui A, Doudnikoff E, Bézard E, Ouro A, Knafo S, Gago B, Quiroga-Varela A, Rodríguez-Oroz MC.

Brain Jun 30;145(6):2092-2107 doi: 10.1093/brain/awac087

Electrophysiological characterization of ectopic spontaneous discharge in axotomized and intact fibers upon nerve transection: a role in spontaneous pain?

Roza C, Bernal L.

Pflugers Archive:European Journal of Physiology. Apr;474(4):387-396. doi: 10.1007/s00424-021-02655-7

Cerebral metabolic pattern associated with progressive parkinsonism in non-human primates reveals early cortical hypometabolism.

Molinet-Dronda F, Blesa J, Del Rey NL, Juri C, Collantes M, Pineda-Pardo JA, Trigo-Damas I, Iglesias E, Hernández LF, Rodríguez-Rojas R, Gago B, Ecay M, Prieto E, García-Cabezas MÁ, Cavada C, Rodríguez-Oroz MC, Peñuelas I, Obeso JA.

Neurobiology of Disease Jun 1;167:105669 doi: 10.1016/j.nbd.2022.105669

2021

Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons.

Claros S, Cabrera P, Valverde N, Romero-Zerbo SY, López-González MV, Shumilov K, Rivera A, Pavia J, Martín-Montañez E, Garcia-Fernandez M.

Cells. Antioxidants (Basel) Dec 24;11(1):41 doi: 10.3390/antiox11010041

Dopamine D4 Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum.

Rivera A, Suárez-Boomgaard D, Miguelez C, Valderrama-Carvajal A, Baufreton J, Shumilov K, Taupignon A, Gago B, Real MÁ.

Cells Dec 23;11(1):31 doi: 10.3390/cells11010031

The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders.

Dasiel O. Borroto-Escuela, Karolina Wydra, Ramon Fores-Pons, Lakshmi Vasudevan, Wilber Romero-Fernandez, Małgorzata Frankowska, Luca Ferraro, Sarah Beggiato, Minerva Crespo-Ramirez, Alicia Rivera, Luisa L. Rocha, Miguel Perez de la Mora, Christophe Stove, Małgorzata Filip and Kjell Fuxe.

Frontiers in Pharmacology Sep 22;(5):1232-1245 doi: 10.3389/fphar.2021.627032

Odontoblast TRPC5 channels signal cold pain in teeth.

Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, Dahl A, Freichel M, Vlachova V, Brauchi S, Roza C, Boehm U, Clapham DE, Lennerz JK, Zimmermann K.

Science Advances Mar 26;7(13):eabf5567 doi: 10.1126/sciadv.abf5567

Activation of the regeneration-associated gene STAT3 and functional changes in intact nociceptors after peripheral nerve damage in mice.

Bernal L, Cisneros E, Roza C.

European Journal of Pain Apr;25(4):886-901 doi: 10.1002/ejp.1718

2020

Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia.

Borroto-Escuela DO, Ferraro L, Narvaez M, Tanganelli S, Beggiato S, Liu F, Rivera A, Fuxe K.

Cells Apr 27;9(5):1077 doi: 10.3390/cells9051077